The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: The importance of Staphylococcus aureus and presence of commensal skin flora.

Background: The role and causality of the microbial ecosystem on the skin in relation to the development of hand eczema (HE) is still unknown.

Objectives: To investigate the prevalence of different bacterial colonisations in HE patients and their association with the severity, symptoms and aetiology of the disease.

Methods: In a retrospective cohort study of 167 HE patients, bacterial swabs from lesional skin were collected for culturing.

Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice.

Loss of FLG causes ichthyosis vulgaris. Reduced FLG expression compromises epidermal barrier function and is associated with atopic dermatitis, allergy, and asthma. The flaky tail mouse harbors two mutations that affect the skin barrier, Flg, resulting in hypomorphic FLG expression, and Tmem79, inactivating TMEM79.

Predictors of severe anaphylaxis in Hymenoptera venom allergy: The importance of absence of urticaria and angioedema.

Background: Severe anaphylaxis (SA) in Hymenoptera venom allergy has been associated with a number of risk factors. However, the effect of several of those risk factors on the severity of anaphylaxis is poorly defined.

Objective: To evaluate risk factors for SA in Hymenoptera venom allergy.