Publications by authors named "Maria Cecilia Fonseca Salgado"
Article Synopsis
- Systemic sclerosis (SSc) is a complex autoimmune disease, and recent clinical trials have prompted an update to the treatment guidelines from the Brazilian Society of Rheumatology.
- A systematic review was conducted using randomized clinical trials, following the PICO framework, with evidence graded by GRADE methodology to create new treatment recommendations.
- Six specific pharmacological recommendations were formulated, including new drugs like rituximab and nintedanib for managing various SSc-related complications, including skin issues and interstitial lung disease.
Antissintetase Syndrome (ASS) is characterized by myositis, Raunaud's phenomenon, fever, intertitial lung disease, mechanic's hands and arthropathy associated with the presence of antibodies against tRNA synthetase, especially anti-Jo-1. This article aims to review the literature on ASS and report two cases where the first is a patient with polymyositis who developed subluxation on the proximal interphalangeal joint of bilateral first right finger after a few years of the disease, associated with pulmonary manifestations and positive anti-JO-1. In the second case, we present a patient with dermatomyositis, who developed a subluxation of the two first fingers, anti-Jo1 positive and chest CT changes, but without clinical evidence of pulmonary involvement.
View Article and Find Full Text PDFObjective: To investigate cognitive deficits in patients with primary Sjögren's syndrome (PSS).
Method: Eighteen patients with PSS, aged between 25 and 61 years, were subjected to a short neuropsychological battery and compared with 18 patients with multiple sclerosis and 18 healthy controls.
Results: The analysis of variance (ANOVA) revealed that the clinical groups had significantly worse performance than the control group on the Rey Auditory Verbal Learning Test 3; (F(2,53) =3.