Publications by authors named "Maria Caterina Crocco"
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system that can lead to long-term disability. The diagnosis of MS is not simple and requires many instrumental and clinical tests. Sampling easily collected biofluids using spectroscopic approaches is becoming of increasing interest in the medical field to integrate and improve diagnostic procedures.
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- Cardiac lipotoxicity, a problem linked to obesity, can lead to cell death in heart cells (cardiomyocytes), but a peptide called PSELT shows promise in protecting against this damage.
- PSELT helps to prevent oxidative stress and maintains important proteins like SELENOT while also regulating the activity of CD36, the main fatty acid transporter, countering the damage caused by palmitate exposure.
- Additionally, PSELT enhances mitochondrial function and structure, preserving energy production and cellular health in cardiomyocytes, as confirmed by various experiments including electron microscopy.
Multiple sclerosis (MS) is one of the most common neurodegenerative diseases showing various symptoms both of physical and cognitive type. In this work, we used attenuated total reflection Fourier transformed infrared (ATR-FTIR) spectroscopy to analyze plasma samples for discriminating MS patients from healthy control individuals, and identifying potential spectral biomarkers helping the diagnosis through a quick non-invasive blood test. The cohort of the study consists of 85 subjects, including 45 MS patients and 40 healthy controls.
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