Publications by authors named "Maria Castineira-Busto"

Aortic stenosis (AS) is the most prevalent degenerative valvular disease in western countries. Transthoracic echocardiography (TTE) is considered, nowadays, to be the main imaging technique for the work-up of AS due to high availability, safety, low cost, and excellent capacity to evaluate aortic valve (AV) morphology and function. Despite the diagnosis of AS being considered straightforward for a very long time, based on high gradients and reduced aortic valve area (AVA), many patients with AS represent a real dilemma for cardiologist.

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Objectives: To determine the risk of mortality and need for aortic valve replacement (AVR) in patients with low-flow low-gradient (LFLG) aortic stenosis (AS).

Methods: A longitudinal multicentre study including consecutive patients with severe AS (aortic valve area [AVA] < 1.0 cm) and normal left ventricular ejection fraction (LVEF).

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Article Synopsis
  • ACE inhibitors (ACEi) and angiotensin II receptor blockers (ARB) show similar survival rates in heart failure patients with low ejection fraction, but their effectiveness in those with preserved ejection fraction post-acute coronary syndrome (ACS) is unclear.
  • A study of 3,006 patients with preserved LVEF (≥40%) after an ACS found no significant differences in outcome measures like mortality and heart failure when comparing ACEi and ARB treatments over an average follow-up of 3.6 years.
  • The results suggest that there is no prognostic advantage of using ACEi over ARB or vice versa in this patient population, highlighting the need for further studies to validate these findings.
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Background: The rate of intracranial haemorrhage after an acute coronary syndrome has been studied in detail in the era of thrombolysis; however, in the contemporary era of percutaneous coronary intervention, most of the data have been derived from clinical trials. With this background, we aim to analyse the incidence, timing, predictors and prognostic impact of post-discharge intracranial haemorrhage in patients with acute coronary syndrome undergoing percutaneous coronary intervention.

Methods: We analysed data from the BleeMACS registry (patients discharged for acute coronary syndrome and undergoing percutaneous coronary intervention from Europe, Asia and America, 2003-2014).

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Article Synopsis
  • This study aimed to explore how angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) impact the occurrence of heart failure (HF) following an acute myocardial infarction (AMI), considering patients' left ventricular ejection fraction (LVEF).
  • Researchers analyzed data from 8,169 AMI patients discharged from two Spanish hospitals between 2010 and 2016, employing various statistical methods to assess the relationship between ACEI/ARB use and heart failure admissions.
  • Findings indicated that while ACEIs/ARBs showed no significant benefit for patients with LVEF over 40%, they significantly reduced HF admissions in patients with LVEF 40% or lower, suggesting
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Introduction: There are conflicting clinical and laboratory data about the effect of dual antiplatelet therapy (DAPT) on cancer incidence, including analysis suggesting an increased cancer risk. This study aims to analyze if there are differences in the incidence of cancer according to the type of P2Y12 inhibitor prescribed (clopidogrel, prasugrel, or ticagrelor), among a population of acute coronary syndrome (ACS) survivors treated with DAPT.

Material And Methods: A retrospective study was conducted among 4229 consecutive ACS patients discharged from a tertiary hospital with DAPT from 2010 to 2016.

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Introduction And Objectives: The long-term prognostic significance of coronary artery dominance pattern in patients with ST-segment elevation myocardial infarction is poorly characterized. We investigated the prognosis of such patients according to whether they had right dominance, left dominance, or codominance.

Methods: This was a retrospective study of 767 patients, who were admitted to hospital between 2007 and 2012 with ST-segment elevation myocardial infarction and treated with primary percutaneous coronary intervention.

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Introduction And Objectives: There is debate regarding the prognostic significance of the absence of significant coronary lesions in patients with non-ST-segment elevation acute myocardial infarction. We investigated long-term prognosis in a contemporary cohort of these patients.

Methods: Retrospective observational study of 5203 patients with acute coronary syndrome.

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Background: Despite encouraging declines in the incidence of heart failure (HF) complicating acute coronary syndrome (ACS), it remains a common problem with high mortality. Being able to identify patients at high risk of HF after ACS would have great clinical and economic impact. With this study, we assessed the usefulness of the GRACE score to predict HF after an ACS.

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Objectives: The risk of stroke after an acute coronary syndrome (ACS) has increased. The aim of this study was to do a comparative validation of the 6-month GRACE (Global Registry of Acute Coronary Events) risk score and CH2DS2VASc risk score to predict the risk of post-ACS ischaemic stroke.

Methods: This was a retrospective study carried out in a single centre with 4229 patients with ACS discharged between 2004 and 2010 (66.

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Introduction And Objectives: The scientific evidence for using beta-blockers after acute coronary syndrome stems from studies conducted in the days before coronary revascularization and in patients with ventricular dysfunction. The aim of this study was to analyze the current long-term prognostic benefit of beta-blockers in patients with acute coronary syndrome and preserved left ventricular ejection fraction.

Methods: We conducted a retrospective cohort study of 3236 patients with acute coronary syndrome and left ventricular ejection fraction ≥ 50%.

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In light of the low cost, the widespread availability of the electrocardiogram, and the increasing economic burden of the health-related problems, we aimed to analyze the prognostic value of automatic frontal QRS-T angle to predict mortality in patients with left ventricular (LV) systolic dysfunction after acute myocardial infarction (AMI). About 467 consecutive patients discharged with diagnosis of AMI and with LV ejection fraction ≤40% were followed during 3.9 years (2.

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