Publications by authors named "Maria C Luzardo"
Sticholysins (Sts) I and II (StI and StII) are pore-forming proteins (PFPs), purified from the Caribbean Sea anemone Stichodactyla helianthus. StII encapsulated into liposomes induces a robust antigen-specific cytotoxic CD8 T lymphocytes (CTL) response and in its free form the maturation of bone marrow-derived dendritic cells (BM-DCs). It is probable that the latter is partially supporting in part the immunomodulatory effect on the CTL response induced by StII-containing liposomes.
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- Vaccine strategies are facing challenges in enhancing CD8 T cell responses due to the need for antigens to bypass cellular membranes for better presentation in antigen-presenting cells (APCs).
- A new approach using sticholysin II (StII), a pore-forming protein from a Caribbean sea anemone, shows promise; it was encapsulated with ovalbumin (OVA) in liposomes to improve CTL activation and memory response in mice.
- The study found that mice treated with the OVA-StII liposomes had stronger anti-tumor effects and CTL responses, indicating that StII may also help mature dendritic cells and function as an effective adjuvant in vaccine development.