Publications by authors named "Maria C Gentile"

Article Synopsis
  • * This study focused on identifying circulating microRNAs, specifically miR-155-5p, in obese patients to determine their risk of developing DM2, using a network-based analysis of expression data.
  • * Findings suggest that miR-155-5p, along with levels of IL-8, Leptin, and RAGE, could serve as effective indicators for identifying obese individuals at higher risk for DM2, making it a potential biomarker for early screening.
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Background and Objectives: The prevalence of gestational diabetes mellitus (GDM) significantly varies across different ethnic groups. In particular, Africans, Latinos, Asians and Pacific Islanders are the ethnic groups with the highest risk of GDM. The aim of this study was to evaluate the impact of ethnicity on pregnancy outcomes in GDM.

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Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response.

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Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis of brain impairment caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, neurotransmitters' alteration, and vascular disease, which lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia. Glucagon-like peptide-1 (GLP-1), a gut released hormone, is attracting attention as a possible link between metabolic and brain impairment.

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Background: Urinary 8-iso-PGF2α, a marker of oxidative stress, is influenced by the activation of NOX2. It is unclear if platelets 8-iso-PGF2α contribute to urinary 8-iso-PGF2α.

Methods And Results: In a cross-sectional study, platelet, urinary, and serum 8-iso-PGF2α were determined in subjects with downregulation (X-linked chronic granulomatous disease [X-CGD], n=25) and upregulation (type II diabetic patients [T2D], n=121) of NOX2 and 153 controls matched for sex and age.

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Article Synopsis
  • CYP3A5 genetic polymorphisms were studied to assess their impact on drug levels of ABT-773, a ketolide antibiotic, which is metabolized by both CYP3A5 and P-glycoprotein.
  • Healthy volunteers with different CYP3A5 genotypes received various doses of ABT-773, and their drug levels were measured to explore the correlation with their genetic makeup.
  • Results indicated that CYP3A5-negative individuals had significantly higher drug levels (AUC and Cmax) than CYP3A5-positive individuals, suggesting that genetic variants in CYP3A5 can influence the pharmacokinetics of ABT-773.
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