The prometastatic relevance of tumor-infiltrating B lymphocytes in laryngeal squamous cell carcinoma.

Objectives: Laryngeal squamous cell carcinomas (LSCCs) typically have an excellent prognosis for stage I tumors but a significant risk of locoregional and distant recurrence for intermediate to advanced disease. This study will investigate the clinical relevance of the tumor microenvironment in a large cohort of treatment-naïve patients affected by stage II-IV LSCC.

Methods: Whole slide-based digital pathology analysis was applied to measure six immune cell populations identified by immunohistochemistry (IHC) staining for CD3, CD8, CD20, CD66b, CD163 and CD38.

Are fascial strains involved in chronic pelvic pain syndrome? An exploratory matched case-control study.

Background: Chronic pelvic pain (CPP) and chronic pelvic pain syndrome (CPPS) do not have a definite cause, even if their impact on quality of life was demonstrated. Furthermore, there is evidence of myofascial dysfunctions in a large number of CPP/CPPS, so that the role of fascia can be hypothesized.

Methods: The aim of this exploratory matched case-control study was to assess whether fascial strains (FS) represent a factor associated with CPP/CPPS.

Working in health and safety at work: reflections on the construction of an integrated policy.

Interventions in work environments, processes, and situations encompass the prevention of diseases and accidents and workers' health promotion. Historically, these actions were originally the responsibility of the Ministry of Labor, being extended to the Ministry of Health, and later to the Ministry of Labor. The aim of this study was to understand and give visibility to the work of the actors working in the different sectors and institutions involved in health and safety at work in the municipality of São Paulo and gain an insight into the barriers to intersectorality and the consequences of the lack of intersectoral collaboration for this area.

What does best evidence tell us about robotic gait rehabilitation in stroke patients: A systematic review and meta-analysis.

Background: Studies about electromechanical-assisted devices proved the validity and effectiveness of these tools in gait rehabilitation, especially if used in association with conventional physiotherapy in stroke patients.

Objective: The aim of this study was to compare the effects of different robotic devices in improving post-stroke gait abnormalities.

Methods: A computerized literature research of articles was conducted in the databases MEDLINE, PEDro, COCHRANE, besides a search for the same items in the Library System of the University of Parma (Italy).

Nutrient content and nutrient availability of sorghum wet distiller's grain in comparison with the parental grain for ruminants.

Background: The present study aimed to compare wet sorghum distiller's grain (WSDG) with sorghum grain (SG) in terms of: (i) chemical composition; (ii) in situ rumen degradation kinetics of organic matter (OM) and neutral detergent fiber (NDF); (iii) crude protein (CP) sub-fractions; (iv) in situ disappearance at 12 and 48 h; and (v) energy values. The WSDG intestinal digestibility (ID) of undegradable crude protein (UCP) was compared to soybean meal (SBM).

Results: Compared to SG, WSDG exhibited: (i) lower (P < 0.

A new organ transplantation location-allocation policy: a case study of Italy.

In this paper, we propose a location model for the optimal organization of transplant system. Instead of simulation approach, which is typical when facing many health care applications, our approach is distinctively based on a mathematical programming formulation of the relevant problem. In particular, we focus on the critical role of time in transplantation process as well as on a spatial distribution of transplant centers.