Publications by authors named "Maria Browne"
Background And Aims: Dwell time is a critical component of automated peritoneal dialysis (APD) prescription, the stage at which transmembrane mass and fluid transfer occur. Loss of prescribed dwell time (LDT) can negatively influence the efficiency of APD. We investigated the incidence of LDT and related causes using APD in the acute care setting at a tertiary care center.
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- * In older animals, inflammation and IL-17 signaling increase after injury and treatment, highlighting a shift in immune response that hinders healing.
- * Targeting this immune response with IL-17-neutralizing antibodies shows promise in improving healing and restoring response to regenerative therapies in older animals.
Senolytic drugs are designed to selectively clear senescent cells (SnCs) that accumulate with injury or aging. In a mouse model of osteoarthritis (OA), senolysis yields a pro-regenerative response, but the therapeutic benefit is reduced in aged mice. Increased oxidative stress is a hallmark of advanced age.
View Article and Find Full Text PDFHeart failure is not only a global problem but also significantly limits the life prospects of these patients. The epidemiology and presentation of heart failure are intensively researched topics in cardiology. The risk factors leading to heart failure are well known; however, the real challenge is to provide effective treatments.
View Article and Find Full Text PDFThe age-old axiom that one is as old as his or her vessels are, calls for ongoing critical re-examination of modifiable risk factors of accelerated vascular ageing in chronic kidney diseases. Attempts to modulate vascular risk with cholesterol-lowering agents have largely failed in advanced chronic kidney disease (CKD). In addition to nitrogen waste products, many pathological biochemical processes also play a role in vascular calcification in chronic kidney damage.
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- - The study in New South Wales examined the effectiveness of an active contact tracing method for follow-up on hepatitis B exposure, contrasting it with the usual passive approach led by general practitioners.
- - In this investigation, staff and clients from a dental practice, identified as a potential hepatitis B exposure site, were contacted multiple times to request blood tests, leading to a participation rate of just 39% among eligible individuals.
- - While the active follow-up required significant resources and staff time ($30,000 and 430 hours), it demonstrated the ability to accurately document participation rates, suggesting that active methods may be beneficial for managing high-risk blood borne virus exposures despite their intensity.
Bondi and beyond. Lessons from three waves of COVID-19 from 2020.
Public Health Res Pract
September 2021
Objectives: To describe local operational aspects of the coronavirus disease 2019 (COVID-19) response during the first three waves of outbreaks in New South Wales (NSW), Australia, which began in January, July and December 2020. Type of program or service: Public health outbreak response.
Methods: Narrative with epidemiological linking and genomic testing.