Publications by authors named "Maria Bremholm Thygesen"
Scand J Clin Lab Invest
November 2021
Article Synopsis
- Oxidative DNA damage plays a key role in various physiological processes, with urinary 8-oxodG often used as a marker to study this damage, though its relation to actual intracellular levels has been unclear.
- A new quantitative kinetic modeling approach shows that, once steady state is reached (around 12 hours), urinary 8-oxodG levels correlate closely with rates of damage and intracellular levels, but not with how quickly cells repair the damage.
- Similar findings apply to the RNA marker 8-oxoGuo, but achieving steady state takes longer (up to 5 days), which is critical for interpreting studies involving these markers.
