Polymerase-1 pathway activation in acute multiple sclerosis relapse.

Background: Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied.

Objective: To assess POL1 pathway expression during acute MS relapse.