Publications by authors named "Maria Benavente-Diaz"
Article Synopsis
- Skeletal muscle stem cells (MuSCs) exhibit functional differences, with cranial MuSCs (like those in extraocular muscles) showing higher growth and repair capabilities compared to limb MuSCs.* ! -
- The study identified that these EOM MuSCs have a delay in differentiation and lower expression of the Myod gene, which is linked to their greater proliferation capacity.* ! -
- Additionally, EOM MuSCs express various extracellular matrix components typical of non-muscle cells, influenced by a unique transcription factor network that remains consistent across different conditions, highlighting their distinct functional identity.* !
Intravital microscopy (IVM) is a powerful technique that enables imaging of internal tissues at (sub)cellular resolutions in living animals. Here, we present a silicone-based imaging window consisting of a fully flexible, sutureless design that is ideally suited for long-term, longitudinal IVM of growing tissues and tumors. Crucially, we show that this window, without any customization, is suitable for numerous anatomical locations in mice using a rapid and standardized implantation procedure.
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- Myogenin is a crucial transcription factor involved in muscle cell differentiation during development and regeneration, but tracking this process has been challenging due to the absence of effective reporters.
- A new mouse model has been created that expresses the tdTOMATO fluorescent protein from the Myogenin gene, which mimics natural Myogenin expression and allows for the identification and tracking of Myogenin-expressing cells during muscle formation and regeneration.
- This innovative model facilitates live imaging of myoblast behavior and cell division, offering researchers a powerful tool to study muscle biology across different developmental stages and in adult tissues.