Publications by authors named "Maria Belen Bosco"
Article Synopsis
- MEN type 1 (MEN1) is an inherited disorder affecting tumor development in glands like parathyroid, pancreas, and pituitary, with an incidence rate of 2-10 cases per 100,000 individuals.
- In a study involving 68 diagnosed patients and 84 relatives, researchers sequenced parts of the MEN1 gene to identify mutations and their prevalence.
- The findings revealed a high prevalence of parathyroid tumors (87.5%), significant mutation rates among familial cases (90%) compared to sporadic cases (51%), and the discovery of seven novel mutations.
Recombinant human growth hormone (rhGH) is used for the treatment of several pathologies, most of them related to growth. Although different expression systems can be used for its production, the milk from transgenic cows is one of the most interesting due to the high rhGH level achieved (5 g/L). We have designed and synthesized short peptides (9 or 10 amino acid long) using Fmoc chemistry and studied their ability to purify rhGH from milk once immobilized on an agarose support.
View Article and Find Full Text PDFChloroplastidic phosphoglycerate kinase (PGKase) plays a key role in photosynthetic organisms, catalyzing a key step in the Calvin cycle. We performed the molecular cloning of the gene encoding chloroplastidic PGKase-1 in the diatom Phaeodactylum tricornutum. The recombinant enzyme was expressed in Escherichia coli, purified and characterized.
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