Glycosylation alterations in serum of Alzheimer's disease patients show widespread changes in -glycosylation of proteins related to immune function, inflammation, and lipoprotein metabolism.

Introduction: There is an increased need for the development of novel blood-based biomarkers for early detection, prevention, or intervention in Alzheimer's disease (AD). This study sought to determine whether serum glycopeptide analysis holds potential for identifying novel diagnostics and prognostics of AD.

Methods: The study involved 195 participants, including 96 patients with an AD diagnosis and 99 controls with no cognitive deficit.