Publications by authors named "Maria Backhaus"
Nucleic Acids Res
August 2024
Article Synopsis
- - Formaldehyde (FA) is a harmful toxin linked to cancer and aging, with genetic mutations in detoxifying enzymes leading to its accumulation and severe health consequences in conditions like AMeD syndrome.
- - The study examined how various DNA repair systems in *C. elegans* respond to excessive FA, identifying three distinct repair mechanisms involved in managing FA-induced DNA damage throughout development and reproduction.
- - Results indicate that the Cockayne syndrome B (CSB) factor plays a key role in resolving FA-related DNA damage, and the antioxidant N-acetyl-l-cysteine (NAC) could offer a therapeutic approach to mitigate FA's harmful effects.
