Immunotherapy-related pneumonitis and the synergic impact of thoracic radiation and preexisting interstitial lung disease.

Purpose Of Review: Immune checkpoint inhibitors (ICIs) are the frontline of therapy for most cancers. Although ICIs are sometimes considered to be less harmful than systemic chemotherapies, ICIs may cause immune-related adverse events, which are cases of off-target inflammation in healthy tissues. Pneumonitis, an immune-related adverse event, is the leading cause of therapy-related mortality with ICIs.

Discovering Potential Bacteriocins Against Pseudomonas fragi: a Subtractive Proteomics and Molecular Dynamic Simulation Study for Food Preservation.

Food preservation is a schematic and scientific procedure employed for the maintenance and improvement of food's quality, shelf life, and nutritional value. Although, on one hand, ancient conventional methods such as freezing, pasteurization, canning, and chemical methods have the potential to lengthen the shelf life of edible substances, but on the other hand, they can deteriorate its nutritional value as well. Present research focuses on the identification of promising bacteriocins against Pseudomonas fragi via subtractive proteomics pipeline as an alternative approach for food preservation.

Screw Dislocations in Chiral Magnets.

Helimagnets realize an effective lamellar ordering that supports disclination and dislocation defects. Here, we investigate the micromagnetic structure of screw dislocation lines in cubic chiral magnets using analytical and numerical methods. The far field of these dislocations is universal and classified by an integer strength ν that quantifies its Burgers vector.

Interaction of human dynein light chain 1 (DYNLL1) with enterochelin esterase () and protective antigen () might be the potential cause of human infection.

The cytoplasmic dynein light chain 1 (DYNLL1) is an important constituent of motor proteins complex. In human it is encoded by gene. It is involved in cargo transport functions and interacts with many viral proteins with the help of short linear consensus motif sequence (K/R) XTQT.

Incommensurate Spiral Order from Double-Exchange Interactions.

The double-exchange model describing interactions of itinerant electrons with localized spins is usually used to explain ferromagnetism in metals. We show that for a variety of crystal lattices of different dimensionalities and for a wide range of model parameters, the ferromagnetic state is unstable against a noncollinear spiral magnetic order. We revisit the phase diagram of the double-exchange model on a triangular lattice and show in a large part of the diagram the incommensurate spiral state has a lower energy than the previously discussed commensurate states.