Proton pump inhibitors and risk for recurrent ischemic events or death in outpatients with symptomatic artery disease.

Bagkground And Aims: The influence of proton pump inhibitors (PPIs) on outcome in patients with symptomatic artery disease remains controversial.

Methods: FRENA is a prospective registry of consecutive outpatients with symptomatic coronary (CAD), cerebrovascular (CVD) or peripheral artery disease (PAD). We compared the risk for subsequent ischemic events or death according to the use of PPIs.