Publications by authors named "Maria Argelia Escobar Sanchez"
Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-α Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study.
Arturo Ramírez-Pacheco Silvia Selene Moreno-Guerrero Luz María Rocha-Ramírez Gabriela Hernández-Pliego María Argelia Escobar-Sánchez
Int J Mol Sci
October 2024
Article Synopsis
- In vitro and in vivo studies indicate that TNF-α, a pro-inflammatory cytokine, is linked to poor cancer prognosis, prompting evaluation of its genetic variations and serum levels in Mexican neuroblastoma (NB) patients.
- Analysis of specific TNF-α genetic polymorphisms (-308 G>A and -238 G>A) revealed significant differences between NB patients and healthy controls, with certain genotypes being associated with decreased risk or susceptibility to NB and unfavorable tumor characteristics.
- Findings suggest that the rs1800629 AA genotype may increase susceptibility to NB and correlate with poorer prognosis, emphasizing the need for further research to validate these associations on a larger scale.
There is evidence that high circulating levels of IL-6 and IL-8 are markers of a poor prognosis in various types of cancer, including NB. The participation of these cytokines in the tumor microenvironment has been described to promote progression and metastasis. Our objective was to evaluate the prognostic role of genetic polymorphisms and serum levels of IL-6 and IL-8 in a cohort of Mexican pediatric patients with NB.
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