Low-level fluoride exposure reduces glycemia in NOD mice.

Unlabelled: Water fluoridation is the most widespread measure to prevent dental caries but its relationship with the development of type-1 diabetes (T1D), which has been increasing by 2-5% worldwide, is not quite well understood.

Aim: This study evaluated if fluoride (F) administered in the drinking water can prevent or reduce the development of T1D in non-obese diabetic (NOD) mice, as well as to explore the underlying mechanisms.

Materials And Methods: Twenty-four weaning NOD mice received water containing 0, 10 or 50 ppm F for 21 days.