Olfactory impairment is prevalent in drug-induced parkinsonism (DIP), and this study investigates the link between dopaminergic dysfunction and smell deficits in DIP patients.
Sixteen DIP patients and thirteen Parkinson's disease patients were assessed using the "Sniffin' Sticks" test and SPECT imaging to observe dopamine transporter binding in the putamen.
Findings revealed that DIP patients with abnormal dopamine uptake experienced significant olfactory function deficits correlated with dopamine binding, while those with normal uptake had mostly typical smell functions, indicating that olfactory issues might signal a Parkinson's-like neurodegenerative process rather than just effects from medication.