Analytical methodologies for metallomics studies of antitumor Pt-containing drugs.

Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategies or new Pt-compounds have been developed with little success.

Evaluation of stability of arsenic species in rice.

Although most edible vegetables do not accumulate As at a high rate, rice, carrots and certain others are exceptions. In addition to nutritional or toxicological considerations, the relatively high level and variety of As species present in rice make it a very suitable matrix for a candidate reference material representative of terrestrial biological samples.An analytical procedure was developed for As speciation in rice based on the use of a 1:1 methanol-water mixture for species extraction, an anion Hamilton PRPX-100 column (at pH 6, and phosphate mobile phase 10 mM), and a cation Hamilton PRP-X200 column (at pH 2.