Prospective assessment of diagnostic tests for pediatric penicillin allergy: From clinical history to challenge tests.

Background: Diagnostic guidelines for penicillin allergy in children recommend cumbersome protocols based partially on data from adults, which may be suboptimal for pediatric use.

Objective: To assess the accuracy of tools for diagnosis of penicillin allergy in children.

Methods: A prospective, multicenter study was conducted in children with reported adverse events related to penicillin, excluding severe reactions.