Publications by authors named "Maria Angelica Mares-Guia"
Article Synopsis
- * Researchers utilized phylogenetic and epidemiological models to map YFV transmission patterns over different epidemic seasons and identified areas of high infection risk linked to low vaccination rates in major urban centers.
- * By analyzing the genomic data, the study revealed three distinct YFV lineages and demonstrated the connectivity between the endemic North and the extra-Amazonian region, suggesting that genomics combined with eco-epidemiology can enhance understanding and strategies for controlling the virus.
Fast surveillance response reveals the introduction of a new yellow fever virus sub-lineage in 2021, in Minas Gerais, Brazil.
Mem Inst Oswaldo Cruz
December 2022
Article Synopsis
- In Brazil, yellow fever virus (YFV) is primarily transmitted through wild mosquitoes and affects non-human primates, with its presence mainly in the Amazon but occasionally spreading to other regions, prompting human cases.* -
- A surveillance network was established in Minas Gerais in 2021, utilizing smartphone technology and collaboration between research and health institutions to monitor YFV in non-human primates, leading to rapid confirmation of the virus through advanced genetic sequencing.* -
- The detection of a new YFV strain in Minas Gerais reinforces the need for ongoing surveillance and quick response strategies to prevent future spillovers to humans, especially since no human cases have been reported in this instance.*
Promoting Responsible Research and Innovation (RRI) During Brazilian Activities of Genomic and Epidemiological Surveillance of Arboviruses.
Front Public Health
August 2021
The Northeast region of Brazil registered the second-highest incidence proportion of Chikungunya fever in 2019. In that year, an outbreak consisting of patients presenting with febrile disease associated with joint pain was reported by the public primary health care service in the city of Natal, in the state of Rio Grande do Norte, in March 2019. At first, the aetiological agent of the disease was undetermined.
View Article and Find Full Text PDFYellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP.
View Article and Find Full Text PDFThe recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil, we generated 18 complete and nearly complete genomes from the peak of the epidemic curve from nonhuman primates (NHPs) and human infected cases across the Espírito Santo and Rio de Janeiro states. Genomic sequencing of 18 YFV genomes revealed the estimated timing, source, and likely routes of yellow fever virus transmission and dispersion during one of the largest outbreaks ever registered in Brazil.
View Article and Find Full Text PDFThe emergence of chikungunya virus (CHIKV) has raised serious concerns due to the virus' rapid dissemination into new geographic areas and the clinical features associated with infection. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples.
View Article and Find Full Text PDFThe dengue virus (DENV), of the genus Flavivirus (Flaviviridae), has four antigenically distinct serotypes, of which DENV-3 is classified into five genotypes. Here, we describe the detection of DENV-3 genotype I in sera of a Brazilian patient travelling from Singapore to Rio de Janeiro, Brazil, by using multiplex real-time RT-PCR, DNA sequencing of the whole envelope protein gene, and phylogenetic analysis. The virus shares ancestry with those identified in Bali, Indonesia, in 2015.
View Article and Find Full Text PDFZoonotic pathogens comprise a significant and increasing fraction of all emerging and re-emerging infectious diseases that plague humans. Identifying host species is one of the keys to controlling emerging infectious diseases. From March 2007 until April 2012, we collected a total of 131 wild rodents in eight municipalities of Rio de Janeiro, Brazil.
View Article and Find Full Text PDFBackground: The purpose of this study was to identify the presence of rickettsia and hantavirus in wild rodents and arthropods in response to an outbreak of acute unidentified febrile illness among Indians in the Halataikwa Indian Reserve, northwest of the Mato Grosso state, in the Brazilian Amazon. Where previously surveillance data showed serologic evidence of rickettsia and hantavirus human infection.
Methods: The arthropods were collected from the healthy Indian population and by flagging vegetation in grassland or woodland along the peridomestic environment of the Indian reserve.
Background: Bartonella is the agent of cat-scratch disease, but is also responsible for more severe conditions such as retinitis, meningoencephalitis, endocarditis and bacillary angiomatosis. Its seroprevalence is unknown in Brazil.
Methods: Patients in an AIDS clinic, asymptomatic at the time of the study, were enrolled prospectively.