Publications by authors named "Maria Angeles Fernandez-Bodega"
Article Synopsis
- The PR-toxin is a harmful mycotoxin produced by the fungus Penicillium roqueforti, which can contaminate food like blue cheese and silage.
- Researchers have identified and silenced a four-gene cluster (prx1 to prx4) that is crucial for PR-toxin production, leading to a significant decrease in toxin output and an unexpected increase in mycophenolic acid, suggesting a relationship between the two metabolic pathways.
- In another fungus, Penicillium chrysogenum, a gene cluster that includes the prx genes was found to be poorly expressed during penicillin production, yet it can produce PR-toxin under different growth conditions, showing further interactions between pathways for secondary metabolite synthesis.
A single gene cluster of Penicillium chrysogenum contains genes involved in the biosynthesis and secretion of the mycotoxins roquefortine C and meleagrin. Five of these genes have been silenced by RNAi. Pc21g15480 (rds) encodes a nonribosomal cyclodipeptide synthetase for the biosynthesis of both roquefortine C and meleagrin.
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- The pga1 gene in Penicillium chrysogenum is crucial for the production of secondary metabolites, including penicillin, chrysogenin, and roquefortine.
- A mutation in the pga1 gene (G42R) enhances the production of these metabolites, while another mutation (G203R) and complete deletion of the gene reduce their levels.
- Increased levels of cAMP do not impact penicillin production, indicating that the pga1 gene primarily regulates metabolite biosynthesis through gene expression rather than through cAMP-mediated signaling.