Publications by authors named "Maria Alice A DE Medeiros"
An Acad Bras Cienc
November 2024
Article Synopsis
- - Candida albicans is the main cause of oral candidiasis, and its growing resistance to drugs has sparked the search for better antifungal treatments, leading researchers to investigate the effects of (-)-fenchone.
- - The study found that (-)-fenchone is effective against C. albicans, including strains resistant to miconazole, demonstrating strong antifungal properties with a Minimum Inhibitory Concentration (MIC) of 8 μg/mL.
- - Negative effects on the fungus do not stem from cell wall or membrane damage, and although (-)-fenchone has some ability to prevent biofilm formation, it doesn't disrupt existing biofilms; it also showed low toxicity, suggesting it could be a viable treatment
