Publications by authors named "Maria Alejandra Aponte"
Article Synopsis
- - The study investigates the effects of etelcalcetide, a treatment for secondary hyperparathyroidism in dialysis patients, on bone health, specifically aiming to improve bone quality and strength without harming bone tissue.
- - Conducted over 36 weeks with 22 participants, the results showed significant reductions in parathyroid hormone levels and increases in bone mineral density and trabecular quality, suggesting positive impacts on bone health.
- - However, bone biopsies indicated a decrease in bone formation rate, highlighting a complex interaction between treatment and bone remodeling processes.
Significance Statement: Renal osteodystrophy (ROD) contributes substantially to morbidity in CKD, including increased fracture risk. Metabolic acidosis (MA) contributes to the development of ROD, but an up-to-date skeletal phenotype in CKD-associated acidosis has not been described. We comprehensively studied associations between acidosis and bone in patients with CKD using advanced methods to image the skeleton and analyze bone-tissue, along with biochemical testing.
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