Publications by authors named "Maria Ahmadi"
Article Synopsis
- SLC26A3, or DRA, is a crucial protein in the intestines that transports anions; its dysfunction leads to specific health issues like chloride-losing diarrhea and increased kidney stone formation.
- Research identified 4,8-dimethylcoumarins as effective inhibitors of DRA, with modifications to their structure yielding compounds with varying potency in inhibiting the protein's function.
- The most promising compound, 8-chlorocoumarin (4k), showed improved potency and effectiveness in reducing constipation in mice, suggesting potential for treating constipation and kidney stone issues in humans.
