Publications by authors named "Maria Adolfina Ruiz"
Article Synopsis
- Exogenous neuroprotective protein neuroglobin (Ngb) is unable to cross the blood-brain barrier, so researchers developed hyaluronate nanoparticles (NPs) to deliver Ngb into the brain for stroke treatment.
- In an animal model of stroke, Ngb-NPs significantly increased survival rates by up to 50% and improved neurological outcomes compared to untreated animals, despite no change in infarct volume or oxidative values.
- Proteomics analysis found 219 proteins with altered expression post-treatment, revealing Ngb's influence on crucial processes related to cell death, mitochondrial function, and regeneration, suggesting potential for advancing stroke and neurodegenerative disorder treatments.
Article Synopsis
- Current stroke therapies can restore blood flow but fail to prevent brain damage or aid recovery in affected areas.
- The neuroglobin protein, important for brain regeneration post-stroke, struggles to cross the blood-brain barrier, complicating its effective use.
- Researchers developed sodium hyaluronate nanoparticles to deliver neuroglobin to nerve cells in stroke-affected rats, showing promising results in transportation and potential neuroprotective effects.
Article Synopsis
- * This research focused on creating a new vaginal tablet featuring Lactobacillus spp. bacteria, ultimately selecting the optimal formulation F4 based on its effective swelling, dissolution, and mucoadhesion properties.
- * The F4 tablets demonstrated quick disintegration in simulated vaginal fluid and provided two distinct release profiles for the bacteria: an immediate release and a sustained release lasting up to 24 hours, while maintaining viable bacteria for 90 days during storage.
The objective of the present study was to investigate the transdermal permeation of cacalol (1) and a mixture of cacalone (2) and 6-epi-cacalone (3) in comparison with diclofenac acid (4) delivered from the same characterized nanoemulsion using Franz diffusion cells (formulae I, II and III). Results show that de Kp, J, Q24, PI and P2 were higher for the acid diclofenac nanoemulsion than for the natural products nanoemulsions. As for the differences between the formulations I and II, with the natural products, Q24, the quantity extracted from skin and P2 were higher in the mixture of 2 and 3 nanoemulsion compared with the corresponding nanoemulsion of 1.
View Article and Find Full Text PDFBackground: Despite the very efficient antitumor activity of conventional chemotherapy, generally high doses of anticancer molecules must be administered to obtain the required therapeutic action, simultaneously leading to severe side effects. This is frequently a consequence of the development of multidrug resistance by cancer cells and of the poor pharmacokinetic profile of these agents.
Objective: In Order to improve the antitumor effect of tegafur and overcome their important drawbacks, we have investigated its incorporation into a drug nanoplatform based on the biodegradable polymer chitosan.