Publications by authors named "Maria A Quinones-Pena"
Article Synopsis
- Overuse of antimicrobials has led to the rise of multidrug-resistant bacteria, complicating the treatment of infections like urinary tract infections (UTIs).
- Autologous bacterial lysates show promise as an alternative treatment for UTIs, but producing individual immunogens can be costly.
- A study on a polyvalent bacterial lysate containing 10 serotypes demonstrated safety in cell cultures and animals, while effectively stimulating the immune response, suggesting it could help manage chronic UTIs and reduce antimicrobial usage.
This study reports the effects of exposing cells of the prototypical enteropathogenic Escherichia coli (EPEC) strain E2348/69 to static magnetic fields (SMF) of varying intensities to observe their capacity to autoaggregate and the effect on cell adherence. The results showed that bacteria exposure over the course of 5 min to an intensity of 53 mT reduced autoaggregation by 28%. However, with intensities of up to 100 mT with the same exposure time, bacteria autoaggregation was reduced by approximately 50%; and after 30 min at the same intensity, it was indistinguishable from that observed in a non-autoaggregative strain.
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