Cat-scratch Disease in the Pediatric Population: 6 Years of Evaluation and Follow-up in a Public Hospital in Chile.

Background: Bartonella henselae is the etiologic agent of cat-scratch disease, which affects the entire world population. Due to how poorly characterized the child population is, the objective was to describe the clinical behavior of this disease in children younger than 16 years of age.

Methods: This was a descriptive study with prospective follow-up of all children younger than 16 years with clinical and serologic diagnoses between 2013 and 2018.

Use of prescription drugs and self-medication among men.

Objective:: To estimate the prevalence, investigate factors associated with the use of medication according to prescription, identify the main pharmaceuticals consumed through self-medication, and the reason for this use among adult men.

Methods:: This cross-sectional population-based study with stratified clustered two-stage sampling was conducted in Campinas, São Paulo, Brazil, in 2008/2009.

Results:: Of the 1,063 men, 45.

Diabetes in the elderly: drug use and the risk of drug interaction.

This study sought to outline the sociodemographic and health profile of elderly persons with reported diabetes, to assess the knowledge and practices regarding treatment options and describe the use of medications and potential risks for drug interactions (DI) in this subgroup. In 2008,a cross-sectional study was conducted of 1,517 elderly citizens in Campinas in which the prevalence of diabetes was estimated and its associations assessed using the Rao-Scott test (p < 0,05).The potential drug interactions were evaluated using the Micromedex® database.

The use of medication and associated factors among adults living in Campinas, São Paulo, Brazil: differences between men and women.

The objective of this study was to verify factors associated with the use of medication by adults, with emphasis on the differences between men and women. It was a population-based, cross-sectional study with cluster sampling conducted in two stages in Campinas in the state of São Paulo in 2008. Among the 2,413 individuals aged 20 or older, the prevalence of use of at least one drug in the three days before the research was 45.

Unravelling the stereoselectivity in 6-exo-trig radical cyclization of alpha,beta-unsaturated ester-tethered sugars. A tale of two stereocenters.

A computational investigation on the origin of the stereoselectivity of 6-exo-trig radical cyclization of alpha,beta-unsaturated ester-tethered sugars has revealed that a boat-like transition state, which keeps the ester in a planar conformation, holds the chiral information. Following this model, the stereocenter to which the ester functionality is connected reports the chirality to the newly formed stereocenter via a 1,4-transfer mechanism.

Synthesis of new heterocyclic derivatives of alpha,alpha-trehalose.

Several novel N-1, N-2, and S-5 tetrazole and 1,3,4-oxadiazole derivatives of alpha,alpha-trehalose disubstituted at C-6,6', with potential synthetic and pharmacological interest were prepared from commercial tetrazoles and 1,3,4-oxadiazoles in reaction with hexa-O-benzyl-6,6'-di-O-triflyl-alpha,alpha-trehalose.

Microwave-assisted efficient preparation of novel carbohydrate tetrazole derivatives.

A series of novel N-1, N-2 and S-5 saccharide substituted tetrazole derivatives linked at anomeric and nonanomeric positions were obtained from commercial tetrazoles under microwave irradiation. Yields are compared with conventional methodologies.

Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments.

Several pharmacopoeias recommend the membrane filtration method for the sterility test of ophthalmic ointments. Isopropyl myristate, a fatty acid ester that exhibits high toxicity mainly against Gram-negative microorganisms, is indicated as a solvent for ointments. In this study, six fatty acid esters (diethyl adipate, diisopropyl adipate, ethyl laurate, ethyl myristate, methyl caprylate and isopropyl palmitate) were evaluated as solvents to replace isopropyl myristate in the sterility test for ophthalmic ointments.

[Physical training practice in women submitted to breast cancer surgery: perception of barriers and benefits].

Unlabelled: The importance of post-mastectomy physical training lies in the prevention of joint limitation, lymphedema, postural alterations, muscle fibrosis or tissue adherence to the surgical area.

Objective: To identify beliefs on physical training practice, perceptions of barriers and benefits in a group of mastectomized women, in accordance with the Health Beliefs Model.

Sample: 30 women assisted at a specialized rehabilitation service for mastectomized women.

In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi.

Fourteen compounds were evaluated for their activity against Trypanosoma cruzi blood stream forms at the concentration of 500 g/ml. Six compounds were active and re-tested at lower concentrations.

The implementation of a surgical antibiotic prophylaxis program: the pivotal contribution of the hospital pharmacy.

Background: Although surgical site infection rates have decreased with the prophylactic use of antibiotics, the inappropriateness of surgical antibiotic prophylaxis is still a worldwide problem. Various strategies have been used to address this problem. This study describes the implementation of a perioperative antibiotic prophylaxis protocol that emphasizes the contribution of the pharmacist.