Smoking, an additional risk factor in elder women with primary open-angle glaucoma.

Purpose: Smoking is a serious public health problem worldwide. Some authors refer to it as the "silent epidemic of the 20th century." It constitutes an important risk factor for ocular pathologies such as age-related macular degeneration (ARMD), diabetic retinopathy, and neuropathy because the toxic effects of tobacco play a key role in the deterioration of eye tissue.

Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma.

Purpose: This study deals with the role of the topical administration of dorzolamide eyedrops on the oxidative/antioxidant status of aqueous humor in patients with primary open angle glaucoma (POAG).

Methods: A case-control study including 130 patients distributed into three groups was carried out: 1) patients with POAG without dorzolamide instillation administration (GG; n=34); 2) patients with POAG with dorzolamide (DG; n=36); and 3) subjects with cataracts (comparative group, CG; n=60). Oxidative activity was measured in the aqueous humor by malondialdehyde determination by the thiobarbituric acid reactive substances assay.

Oxidative stress in primary open-angle glaucoma.

Purpose: To analyze oxidative stress in primary open-angle glaucoma (POAG).

Material And Methods: A case-control study including 90 eyes of 90 patients who needed antiglaucomatous surgery in the course of POAG (glaucoma group, n=50) and from patients who were operated of nonpathologic cataracts (cataract group, n=40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) test and total antioxidant status in the aqueous humor samples of both groups were determined.