{[()-(1,3-Benzodioxol-5-yl)methyl-idene]amino}thio-urea.

The synthesis and crystallographic analysis of the title compound, CHNOS, are reported. The compound crystallizes in the monoclinic space group 2/, revealing characteristic bond lengths and angles typical of thio-semicarbazone groups. The supra-molecular organization primarily arises from hydrogen bonding and π-π stacking inter-actions, leading to distinctive dimeric formations.

Inactivation of maternal Hif-1α at mid-pregnancy causes placental defects and deficits in oxygen delivery to the fetal organs under hypoxic stress.

A critical transition occurs near mid-gestation of mammalian pregnancy. Prior to this transition, low concentrations of oxygen (hypoxia) signaling through Hypoxia Inducible Factor (HIF) functions as a morphogen for the placenta and fetal organs. Subsequently, functional coupling of the placenta and fetal cardiovascular system for oxygen (O) transport is required to support the continued growth and development of the fetus.