Publications by authors named "Maria A Lai"
Article Synopsis
- Inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, are chronic conditions affecting the gastrointestinal tract, with unclear causes but potential metabolic alterations that could inform therapeutic strategies.
- Using gas chromatography-mass spectrometry, researchers analyzed plasma and biopsies from IBD patients and a control group, revealing distinct metabolomics profiles between Crohn disease and ulcerative colitis.
- Findings indicate that changes in energy metabolism and specific metabolites like lactic acid and ornithine are altered in IBD, suggesting that metabolomics could play a role in understanding disease mechanisms and advancing precision medicine.
Article Synopsis
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- The identified error in the original paper has been addressed and corrected.
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Article Synopsis
- Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, leads to changes in gut microbiota composition, but it remains unclear if these changes cause or result from the inflammation.
- A study of 183 individuals revealed significant differences in both microbial profiles and metabolites, with specific bacteria increasing and decreasing in IBD patients compared to healthy controls.
- The findings suggest that analyzing both microbiota and metabolites together can help distinguish IBD patients from healthy individuals, indicating the importance of an inter-omics approach in exploring metabolic processes related to the disease.
Article Synopsis
- The DICA classification helps evaluate patients with diverticulosis and diverticular disease by predicting the risk of diverticulitis and potential need for surgery.
- In a study of 1651 patients, it was found that higher DICA severity correlated with increased rates of diverticulitis recurrence and surgical intervention.
- Therapy, particularly mesalazine-based treatments, showed effectiveness in preventing diverticulitis in certain DICA classifications, specifically DICA 2 patients.
Background/aims: No comparative studies are available, as yet, in Italy, concerning the prevalence of irritable bowel syndrome (IBS) in urban and rural areas. The aim is to compare the prevalence of IBS in Italian urban and rural areas.
Methods: 950 subjects were randomly selected from each area and completed a questionnaire regarding demographic data and the Rome II questionnaire.
Background And Aim: In celiac disease (CD) the role of a gluten-free diet (GFD) on gastroesophageal reflux disease-related symptoms (GERD-rs) is unclear. The aim of this study was to establish the recurrence of GERD-rs, in CD patients with nonerosive reflux disease (NERD).
Methods: From a total of 105 adult CD patients observed, 29 who presented with the NERD form were enrolled in the study.