Publications by authors named "Maria A Becquer"
Context: The recombinant human erythropoietin (rHuEPO) stimulates the erythropoiesis process. Because this glycoprotein has a short half-life, it needs to be administrated two to three times a week. One of the technics to solve this issue is the PEGgilation.
View Article and Find Full Text PDFAntiatherosclerotic effect of an antibody that binds to extracellular matrix glycosaminoglycans.
Arterioscler Thromb Vasc Biol
March 2012
Article Synopsis
- The study investigates a chimeric monoclonal antibody (chP3R99) that targets sulfated molecules, showing potential in preventing atherosclerosis by blocking the retention and oxidation of low-density lipoproteins (LDL) in blood vessels.
- ChP3R99 significantly inhibited LDL retention and oxidation in laboratory settings and demonstrated a 22-fold reduction in atherosclerosis risk when administered to rabbits.
- The findings suggest that immunotherapy using anti-sulfated glycosaminoglycan antibodies can be an effective strategy for preventing atherosclerosis, as it leads to a reduced macrophage infiltration and preserved vascular health.
The present study was aimed at the preparation and performance evaluation of Intacglobin-loaded liposomes for selective drug presentation to the lungs. Egg phosphatidylcholine- and cholesterol-based liposomes (1:1 and 1:0.25 mol/mol) were prepared by a dehydration-rehydration procedure.
View Article and Find Full Text PDFThe multiple-dose strategy with the monoclonal ior EGF/r3 antibody, in xenograft bearing nude mice, was supported upon the basis of its integrated pharmacokinetic-pharmacodynamic relationship, according to both the temporal (K(e0)=0.0015+/-0.000035h(-1)) and the time-independent sensitivity (C(50%)(ss), 9.
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