Early detection of ketoprofen-induced acute kidney injury in sheep as determined by evaluation of urinary enzyme activities.

Objective: To evaluate early indicators of renal tissue destruction and changes in urinary enzyme activities in sheep during the first hours after acute kidney injury induced by administration of an overdose of an NSAID.

Animals: 12 adult female sheep.

Procedures: Acute kidney injury was induced in 6 sheep by administration of ketoprofen (30 mg/kg, IV) and detected by evaluation of urinary protein concentration, iohexol clearance, and results of histologic examination.