Effects of TrkA inhibitory peptide on cancer-induced pain in a mouse melanoma model.

Purpose: Tropomyosin receptor kinase (Trk) A, a high-affinity receptor of nerve growth factor, is a therapeutic target for both noxious and neuropathic pain. The present study examined the effects of an inhibitory peptide of Trk activity (IPTRK) 3 that inhibits TrkA activity on cancer-induced pain in a mouse melanoma model.

Methods: The hind paws of mice were inoculated with B16-F1 mouse melanoma cells on day 0.

[The use of rocuronium in a patient with Becker muscular dystrophy].

We report a case of thoracoscopic pulmonary resection for pneumothorax in a patient with Becker muscular dystrophy The sensitivity of nondepolarizing muscle relaxant in a patient with muscle dystrophy is reportedly higher than in a patient without muscle disease, and the duration of the effect is known to be prolonged. In a 26-year-old man (height 160 cm, weight 39 kg) with Becker muscular dystrophy, general anesthesia was induced with target controlled infusion of propofol (3.0 microg x ml(-1)) and 0.

[Educational efficacy of computer software showing the effect-site concentration of fentanyl in anesthesia training].

Background: We investigated the efficacy of computer software showing the effect-site concentration of fentanyl in anesthesia training.

Methods: All patients were randomly divided into the following three groups. Anesthesia management was performed with a pharmacokinetic simulation program by anesthesia residents with experience in using it for less than 3 months (P (+) group, n = 32).

[Perioperative anesthetic management of a patient with multiple sclerosis].

We report general anesthesia for a patient with multiple sclerosis (MS). A 40-year-old male patient with a 13-year history of MS was scheduled for laparoscopic surgery. The symptoms of MS had been exacerbated during feverish state or under surgical stress in the previous surgeries.

[Continuous intravenous administration of fentanyl reduces tenesmus after transurethral resection of the prostate (TUR-P)].

Background: The relief from tenesmus is important after transurethral resection of the prostate (TUR-P). We evaluated the effect of continuous intravenous administration of fentanyl on the tenesmus.

Methods: Eleven patients receiving fentanyl infusion (fentanyl group) were compared with fourteen patients without fentanyl infusion (control group) retrospectively.

[Two cases of atraumatic iliopsoas hematoma].

We report two cases of atraumatic iliopsoas hematoma. First patient was a 76-year-old man admitted to our hospital from appetite loss. Blood transfusion did not improve his anemia.