Publications by authors named "Mari Saito-Oba"
Background: An international retrospective cohort study was conducted to clarify the survival advantage of combination therapy with locoregional and systemic therapy (ST) in oligometastatic breast cancer (BC).
Methods: Patients with oligometastatic BC diagnosed from 2007 to 2012 were enrolled in center hospitals in China, Korea and Japan. It was defined as a low-volume metastatic disease at up to five sites and not necessarily in the same organ.
Objectives: The 23-valent pneumococcal polysaccharide vaccine (PPSV23) was included in Japan's national immunisation programme for older adults in 2014. While vaccination coverage has increased following the implementation of the national immunisation programme, little is known about the factors that have influenced changes in PPSV23 uptake in Japan. This study aimed to investigate the effects of municipality-level activities implemented to improve vaccine uptake during the fiscal year 2015 (April 2015-March 2016).
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- Idiopathic nephrotic syndrome (INS) is the most common chronic kidney disease in children, where many respond to steroids, but a subset develops complex forms that resist treatment or frequently relapse.
- Around 10-20% of children on immunosuppressive drugs still experience serious relapses, prompting the use of rituximab (RTX) in complicated cases.
- A study is underway to assess the effectiveness and safety of mycophenolate mofetil (MMF) as a follow-up treatment after RTX, aiming to improve long-term outcomes for these patients.
Background: Persistent proteinuria seems to be a risk factor for progression of renal disease. Its reduction by angiotensin-converting inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) is renoprotective. Our previous pilot study showed that 2-year lisinopril therapy is effective and safe for children with mild IgA nephropathy.
View Article and Find Full Text PDFBackground: Eighty percent of children with steroid-sensitive nephrotic syndrome (SSNS) relapse within 2 years and 40-50% patients show frequently-relapsing nephrotic syndrome (FRNS). Patients showing a relapse within 6 months after initial remission are at high risk of FRNS. Since frequent prednisolone treatment for FRNS induces severe prednisolone side effects, development of a treatment to prevent patients from shifting to FRNS is desirable.
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- A randomized phase II study evaluated a Wilms' tumor gene 1 (WT1) vaccine combined with gemcitabine (GEM) against GEM alone for advanced pancreatic ductal adenocarcinoma (PDAC).
- Patients who received the WT1 vaccine showed prolonged progression-free survival (PFS) and a higher overall survival rate at 1 year compared to those on GEM alone, especially in metastatic cases.
- The treatment was well tolerated and resulted in significant immune responses, indicating that the combination could be beneficial for managing advanced PDAC.
We determined the predicting factors of early-onset group B streptococcal (EOGBS) infection in neonates who were born to GBS carrier mothers with inadequate intrapartum antibiotic prophylaxis (IAP). Medical records of all neonates born from January 1, 2008 to April 1, 2010 were reviewed. Inadequate IAP was defined as delivery less than 4 hours (h) after the first administration of antimicrobial.
View Article and Find Full Text PDFBackground And Objectives: An open-label, multicenter, randomized phase II trial was conducted from July 1, 2005 to March 29, 2011 to compare two protocols for treating children with frequently relapsing nephrotic syndrome using microemulsified cyclosporine.
Design, Setting, Participants, & Measurements: Ninety-three children with frequently relapsing nephrotic syndrome were randomly assigned to group A (n=46) or group B (n=47). In both groups, the 2-hour postdose cyclosporine level was monitored.