Publications by authors named "Mari Mino-Kenudsen"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can lead to serious immune-related adverse events (irAEs), with ICI-related myocarditis (irMyocarditis) being particularly dangerous and the most lethal among these events.
- Researchers explored immune responses in the heart, tumors, and blood of 28 patients with irMyocarditis compared to 23 controls, using advanced techniques like single-cell RNA sequencing and proteomics.
- Key findings revealed a unique presence of specific immune cells in irMyocarditis heart tissue, distinct T cell responses in heart vs. tumor, and identified novel biomarkers related to fatality that could inform future therapies.
