Thymidine phosphorylase is regulated by tamoxifen in T47D breast cancer cell line.

Background: Thymidine phosphorylase (TP) has diverse functions within cells, including increasing the sensitivity of cancer cells to cytotoxic drugs including 5-fluorouracil (5-FU) and methotrexate. However, the regulators of TP still remains largely unknown.

Method: In this study, we examined whether tamoxifen has specific effects on TP expression in the T47D breast cancer cell line.