Publications by authors named "Mari Ervasti"

Background: Excessive stress has a negative impact on many aspects of life for both individuals and societies, from studying and working to health and well-being. Each individual has their unique level of stress-proneness, and positive or negative outcomes of stress may be affected by it. Technology-aided interventions have potential efficacy in the self-management of stress.

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Objective: Hepcidin, a small 25 amino-acid antimicrobial peptide, has a significant role in the regulation of iron homeostasis. Pro-hepcidin, an 84 amino-acid peptide, is a precursor of the active hepcidin. The main aim of this study was to examine the association of maternal serum pro-hepcidin with cord blood pro-hepcidin levels in term pregnancies, and whether maternal and newborn iron status measurements correlate with the pro-hepcidin level.

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Objective: To investigate the associations between maternal iron status, pregnancy outcome and newborn iron status using sensitive and specific red blood cell indices reflecting iron-deficient erythropoiesis.

Design And Setting: Cross-sectional study in Kuopio University Hospital, Finland.

Population: One hundred and ninety-two pregnant women and their full-term newborns (cord blood).

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Background: At present, measurements of troponins play a key role in the diagnosis of myocardial infarction. There is a consensus that a turnaround time (TAT) of 1 h or less should be achieved for cardiac marker assays. However, little is known about the real delays between the patient's arrival at the emergency department (ED) and the reporting of the test.

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There is evidence that an elevated erythropoietin (EPO) concentration is associated with signs of iron deficient erythropoiesis. The aim of this study was to evaluate the iron status by means of novel cellular indices and serum iron markers and to determine whether these are associated with EPO and pH in the venous cord blood of 193 full-term newborns. There were positive correlations between EPO and the percentage of hypochromic red blood cells (%HYPOm) and reticulocytes (%HYPOr) [r = 0.

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Objectives: Detection of iron deficiency during pregnancy with hemoglobin (Hb) and serum measurements is insignificant as the measurements may be affected by e.g. hemodilution or accelerated erythropoiesis.

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Background: The aims of this study were to assess the relationship between red blood cell and reticulocyte indices and biochemical iron status measurements, and to define reference values of these markers in the cord blood of newborns.

Methods: In cord blood samples from 199 full-term newborns, cellular indices were assessed using an ADVIA 120 hematology system and iron status was analyzed by measurement of serum iron, transferrin, transferrin saturation (TfSat), transferrin receptor (TfR) and ferritin.

Results: Cellular hemoglobin in red blood cells or reticulocytes was independent of serum iron markers such as TfSat, TfR and ferritin.

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Background: A quantitative flow cytometric (FCM) method for transferrin receptor (TfR) expression on reticulocytes was developed and the results were compared with the markers of iron status.

Methods: A quantitative FCM analysis was performed using the Quantum Simply Cellular kit, according to which the antibody binding capacity (ABC) of TfR expression on reticulocytes was measured using a monoclonal antibody (CD71). Thiazole orange dye was used to identify reticulocytes.

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