Publications by authors named "Margret Eckhard"
Nintedanib (NIN), a multi-tyrosine kinase inhibitor clinically approved for idiopathic pulmonary fibrosis and lung cancer, is characterized by protonation-dependent lysosomotropic behavior and appearance of lysosome-specific fluorescence emission properties. Here we investigate whether spontaneous formation of a so far unknown NIN matter within the acidic cell compartment is underlying these unexpected emissive properties and investigate the consequences on lysosome functionality. Lysosomes of cells treated with NIN, but not non-protonatable NIN derivatives, exhibited lysosome-associated birefringence signals co-localizing with the NIN-derived fluorescence emission.
View Article and Find Full Text PDFChemical substances are of utmost importance for the biotic interactions between animals and their predators/parasites; many of these semiochemicals are emitted for defence purposes. One of the most deterrent and toxic biogenic substances we know of is hydrogen cyanide, which can be stored by certain insects, millipedes, centipedes and arachnids in the form of stable and less volatile molecules. The aim of this study was to analyse the biology and chemistry of such a defence mechanism in a geophilomorph centipede (Chilopoda).
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- The scientists studied new silver compounds that might help fight cancer, especially in cases where other drugs don’t work.
- They used various techniques to analyze these compounds and understand how they work against different cancer cells.
- The results showed that one type of silver compound was very effective against a certain cancer type and caused cells to die in a unique way, which could make it a good treatment option for difficult cancers.
Article Synopsis
- Oxaliplatin demonstrates better effectiveness for treating colorectal cancer than cisplatin, but understanding its cellular distribution and why some tumors respond better remains limited.
- This study utilized advanced imaging techniques to analyze how oxaliplatin accumulates within various parts of three human colon cancer cell lines, finding that it tends to cluster in cytoplasmic organelles and affect nuclear structures.
- In comparing a sensitive cell line (HCT116 wt) to its oxaliplatin-resistant counterpart (HCT116 OxR), both showed similar platinum distribution, but the resistant line had a significantly higher accumulation of the oxalate ligand, indicating a mechanism of resistance.
Background: Biomineralization, e.g., in sea urchins or mollusks, includes the assembly of mesoscopic superstructures from inorganic crystalline components and biopolymers.
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