Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.

Exhaled nitric oxide (FE) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FE is decreased. To understand if reduced FE is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FE in 34 infants with CF prior to clinical symptoms and in 68 healthy controls.