Publications by authors named "Margot Fernandez Hernandez"
Cancers (Basel)
November 2020
Article Synopsis
- MicroRNAs (miRNAs) play key roles in gene regulation for both normal and disease-related cellular processes, with a focus on Burkitt lymphoma (BL), a type of cancer driven by the MYC gene.
- A study using small RNA sequencing identified 26 miRNAs with significant expression differences between BL cell lines and normal germinal center B (GC-B) cells, confirming the role of five miRNAs in primary BL tissues.
- The study specifically highlighted miR-378a-3p as an oncogenic miRNA in BL, with its inhibition leading to reduced tumor growth and confirmed target genes, IRAK4 and MNT, which contribute to its growth-regulatory effects.
