Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining.

[Complications After Transcatheter Aortic Valve Implantation].

Purpose: to assess rate of complications after transcatheter aortic valve implantation (TAVI).

Material And Results: Our study included 99 patients who underwent TAVI. Frequent complications were: bleeding not requiring surgical hemostasis (17.

The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline.

Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is an increasing problem for senior populations. Its causes are poorly understood and therapies are largely ineffective. Neurons, with high energy and oxygen requirements, are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes.

[DEXMEDETOMIDINE SEDATION DURING TRANSCATHETER AORTIC VALVE IMPLANTATION.].

The Aim: to determine the efficacy and safety of dexmedetomidinefor sedation and analgesia during transcatheter aortic valve implantation (TA VI) withfemoral access.

Materials And Methods: the study included 34 high-risk surgical patients with "critical aortic stenosis". All patients underwent TAVI with femoral access.

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.

GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors.

[Monitoring of haemodynamics and function of the aortic prosthesis during transcatheter aortic valve replacement].

Purpose: To find an advisability of use of invasive monitoring of intracardiac haemodynamics during transfemoral transcatheter aortic valve replacement.

Patients And Methods: The study included 12 patients underwent transfemoral transcatheter aortic valve replacement (TTAVR). All patients were monitored according to Harvard standard.

GHK and DNA: resetting the human genome to health.

During human aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells.

A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in patients with uncontrolled type 2 diabetes.

Objective: To test cognitive behavioral therapy for adherence and depression (CBT-AD) in type 2 diabetes. We hypothesized that CBT-AD would improve adherence; depression; and, secondarily, hemoglobin A1c (A1C).

Research Design And Methods: Eighty-seven adults with unipolar depression and uncontrolled type 2 diabetes received enhanced treatment as usual (ETAU), including medication adherence, self-monitoring of blood glucose (SMBG), and lifestyle counseling; a provider letter documented psychiatric diagnoses.

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.

Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions. Recently, a new mechanism of aging-detrimental epigenetic modifications-has emerged. Thus, compounds that possess antioxidant, anti-inflammatory activity as well as compounds capable of restoring copper balance and proper gene functioning may be able to prevent age-associated cognitive decline and ward off many common neurodegenerative conditions.

[Prolonged pulmonary artery pressure monitoring in patients with pulmonary hypertension].

Pulmonary artery pressure (PAP) was monitored for 24-48 hours in 10 and 8 patients with primary and secondary pulmonary hypertension, respectively. The data obtained were compared with results of prolonged PAP monitoring in 2 healthy volunteers. Variability of mean PAP was 7.

Isolated replacement of the mitral leaflets and "Mercedes"-plastics of the giant left atrium: surgery for patients with left ventricle dysfunction and left atrium enlargement.

Background: The main goal of the present surgery is to develop a new complex of surgical procedures for patients with long-standing mitral valve incompetence, severe left atrium (LA) and left ventricle (LV) enlargement (secondary cardiomyopathy).

Methods: Seven patients were operated on using a new technique. Normal LA shape and size were restored by symmetrical "Mercedes"-plastics of the posterior LA wall.

[The serodiagnosis of viral hepatitis C and B in different population groups].

Data on the frequency of detection of serological markers of hepatitis C and B viruses using enzyme immunoassay for examinations of blood donors in different regions of the country, of patients with hepatitis of obscure etiology and patients with hemophilia regularly receiving hemostatic therapy are presented. The rate of detection of antibody to hepatitis C (anti-HCV) in reserve donors varied from 2% (Baltic states) to 9.2% (Moldavia), that of the carrier state of HBsAg from 0.

[Immunodiagnosis of HIV infection in the transfusion service].

Enzyme immunoassay (EIA) is the basic method of the laboratory diagnosis of HIV-infection used as the first component of donors' screening. The possibility of nonspecific reactions presents a significant shortcoming of this method. An algorithm involving three stages has been elaborated to investigate donors for anti-HIV antibodies and to verify seropositive samples.

[Comparative evaluation of the immunoenzyme test systems for HIV-1 and HIV-2 infections].

Comparative investigations of enzyme immunoassay systems for the diagnosis of HIV-infection were conducted in panels with HIV-1 and HIV-2-positive and negative samples. It has been shown that immunodiagnostic reagents produced by the firms "Abbott" (USA) and "Behring" (FRG) possess the highest sensitivity and specificity. It has been established that the test-systems for HIV-1 cannot identify HIV-2-positive samples due to the absence of cross-reactivity.

[Serological markers of viral infections and various indicators of immunity in patients with hemophilia].

The authors have studied the incidence rate for markers of viruses of AIDS (HIV), hepatitis B (HBV) and cytomegalia (CMV), as well as certain parameters of antiinfectious defense in hemophilia patients. A high incidence rate of HBV and CMV markers was established in the investigated patients, and among them no seropositive subjects, by antibodies to HIV, were detected. In the presence of a low incidence rate of chronic HBsAg-carriership in this category of patients, a significant number of immune subjects was observed, that correlated with a relative stability of such immunity parameters as concentration of serum immunoglobulin G and the level of circulating immune complexes.

[Problem of differential diagnosis of hepatitis in donors of blood for plasmapheresis].

The data obtained as a result of a serological study of virus A and B hepatitis markers by the RIA in immune plasmapheresis donors among whom there were cases of group hepatitis allowed one to exclude the etiological role of hepatitis virus A and B in immune plasma-pheresis donors.