PD-L1 expression is regulated by microphthalmia-associated transcription factor (MITF) in nodular melanoma.

Malignant melanoma (MM) is known to avoid the host's immune response. Studies on in vitro melanoma cell lines link the microphthalmia-associated transcription factor (MITF) with the regulation of the PD-L1 expression. It seems that MITF affects the activation of the gene responsible for PD-L1 protein expression.

Undifferentiated pleomorphic sarcoma in oropharyngeal mucosa of patients with multiple basal cell carcinomas.

Malignant mesenchymal tumors of oropharyngeal mucosa are rare. Those with fibroblastic and histiocytic differentiation in the skin are called atypical fibroxanthoma (AFX) and in the soft tissue undifferentiated pleomorphic sarcoma (UPS). Here we present a case of an older patient with a history of multiple basal cell carcinomas and recently with a rapidly growing polypoid lesion in the mucosa of posterior oropharyngeal wall with AFX/UPS morphology.

Dentofacial deformity and orthognatic surgery: Influence on self-esteem and aspects of quality of life.

This study aimed to assess the extent to which psychosocial and functional aspects are affected in orthognathic surgery patients. The Oral Health Impact Profile (OHIP-CRO14), Orthognathic Quality of Life Questionnaire and Self-Esteem (SE) Scale were used. The sample included 110 Caucasian subjects (73% females) aged 19-54 years.

Pancreatic Carcinoma Metastatic to the Gingiva.

Metastatic tumors to the oral cavity are uncommon, representing approximately 1% of all cases of oral malignant lesions even when a metastatic disease is present. The 53-year-old female is presented complaining of abdominal pain, weight loss, and a loose stool recurring not more than three times per day. A computed tomography (CT) scan of the abdomen showed a retroperitoneal mass expanding along the body of the pancreas.

Microbiology of wound infection after oral cancer surgery.

Introduction: The aim of present study is to investigate the most common infection pathogen found in the postoperative wounds, following surgical treatment of oral and oropharyngeal cancer, in order to identify the most suitable antibiotic treatment.

Patients And Methods: We analyzed patients with squamous cell cancer of oral and oropharyngeal region. In patients who developed postoperative wound infection, wound swabs were taken from three different sites: the cannula, wounds on the neck and wounds in the oral cavity.

Kaposi's sarcoma in an HIV-negative chronic lymphocytic leukemia patient without immunosuppressive therapy: A case report.

Kaposi's sarcoma is a neoplasm of endothelial cells. That vascular tumor is usually limited to the skin, but it may involve mucous membranes, visceral organs, and lymph nodes. Serological evidence has shown that human herpesvirus 8 infection is required for the development of Kaposi's sarcoma.

Multivariate analysis of risk factors for postoperative wound infection following oral and oropharyngeal cancer surgery.

Purpose: The goal of this study was to identify risk factors for wound infections in patients with oral cancer who underwent surgical procedures.

Materials And Methods: This study included 195 patients who underwent surgical treatment of oral and oropharyngeal cancer over a 7-year period. Wound infection was defined as the occurrence of purulent content from the wound or as an appearance of exudate with signs of local infection and positive cultures taken from the wound.

Fine needle aspiration cytology in the evaluation of parotid gland tumors.

Main objective of this study was to evaluate the usefulness and accuracy of fine needle aspiration cytology (FNAC) diagnosis of parotid masses to distinguish reliably between benign and malignant lesions. In the period of 5 years, 214 parotid glands were resected at the Rijeka University Hospital Center (Croatia), but 176 patients had cytopathological and histopathological diagnoses and therefore fulfilled the criteria for study. The results of the FNAC were analyzed and compared to the corresponding histopathological diagnosis obtained from the surgical specimen.

Neurectomy of the trigeminal nerve branches: clinical evaluation of an "obsolete" treatment.

Introduction: After all options of conservative treatment of trigeminal neuralgia have been exhausted, surgical methods are used. Peripheral neurectomy is one of the simplest among them. It is a relatively obsolete method, but can still be useful and effective.

Risk factors for wound infection after oral cancer surgery.

Wound infection is a common complication after oral cancer surgery and may result in significant functional morbidity, poor cosmetic results and prolonged hospitalization. The purpose of this study was to identify the most important factors contributing to operative wound infections in patients with oral and oropharyngeal cancer. A retrospective review of complications in 111 patients after oral and oropharynx cancer surgery with an immediate reconstruction is presented.