Publications by authors named "Margherita Vaselli"
Early detection of (pre)malignant esophageal lesions is critical to improve esophageal cancer morbidity and mortality rates. In patients with advanced esophageal adenocarcinoma (EAC) who undergo neoadjuvant chemoradiation therapy, the efficacy of therapy could be optimized and unnecessary surgery prevented by the reliable assessment of residual tumors after therapy. Optical coherence tomography (OCT) provides structural images at a (sub)-cellular level and has the potential to visualize morphological changes in tissue.
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- EB-PS-OCT is a cutting-edge imaging technique that surpasses high-resolution CT in detecting pulmonary fibrosis by 50 times, effectively highlighting collagen birefringence.* -
- The study focuses on using EB-PS-OCT to visualize and quantify fibrosis in patients with interstitial lung diseases (ILD), comparing its findings to histological standards and HRCT images.* -
- Results from 19 patients showed a successful quantification of fibrosis using EB-PS-OCT, with its findings correlating well with histology, indicating its potential as a valuable tool in clinical assessments of lung diseases.*
A non-invasive diagnostic tool to assess remodeling of the lung airways caused by disease is currently missing in the clinic. Measuring key features such as airway smooth muscle (ASM) thickness would increase the ability to improve diagnosis and enable treatment evaluation. In this research, polarization-sensitive optical coherence tomography (PS-OCT) has been used to image a total of 24 airways from two healthy lungs and four end-stage diseased lungs , including fibrotic sarcoidosis, chronic obstructive pulmonary disease (COPD), fibrotic hypersensitivity pneumonitis, and cystic fibrosis.
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