Publications by authors named "Margherita E Pezzi"
The prognosis of patients with oral squamous carcinoma (OSCC) largely depends on the stage at diagnosis, the 5-year survival rate being approximately 30% for advanced tumors. Early diagnosis, including the detection of lesions at risk for malignant transformation, is crucial for limiting the need for extensive surgery and for improving disease-free survival. Saliva has gained popularity as a readily available source of biomarkers (including cytokines) useful for diagnosing specific oral and systemic conditions.
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- This study investigates the metabolic composition of saliva to find non-invasive diagnostic biomarkers for oral health, focusing on submandibular/sublingual saliva, which has not been thoroughly analyzed before.
- Researchers analyzed saliva samples from 20 healthy individuals using nuclear magnetic resonance and identified varying metabolites present in different saliva types: whole, parotid, and submandibular/sublingual.
- The findings revealed specific metabolites unique to each saliva subtype and laid the groundwork for further research into salivary biomarkers related to oral and systemic health issues.
Unlabelled: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malignancies and systemic diseases is rapidly increasing. The present systematic review was developed for answering the question: "Are salivary microRNAs reliable biomarkers for diagnosis of cancer and systemic diseases?"
Methods: The application of inclusion and exclusion criteria led to the selection of 11 papers.