Publications by authors named "Margaux Louchet"
Article Synopsis
- The study aimed to evaluate trends in exposure to harmful drugs among pregnant women in France from 2013 to 2019.
- It involved analyzing data from over 5 million pregnancies to determine the prevalence of exposure to teratogenic and fetotoxic drugs during critical pregnancy periods.
- Results indicated that while there was a notable decrease in overall harmful drug exposure during this time, specific drugs such as retinoids and NSAIDs were the most commonly used.
Studies on drug utilization in western countries disclosed that about nine over ten women use at least one or more drugs during pregnancy. Determining whether a drug is safe or not in pregnant women is a challenge of all times. As a developing organism, the fetus is particularly vulnerable to effects of drugs used by the mother.
View Article and Find Full Text PDFFrequency of differential placental transfer to twins of maternal antiretroviral medications.
Eur J Obstet Gynecol Reprod Biol
January 2021
Background: Placental passage of drugs in twins is poorly understood, and is unknown regarding antiretrovirals (ARVs). In the event of large differences in the exposure of 2 twins to the same maternal therapy, this could have a clinical impact in terms of prevention of perinatal HIV transmission or adverse effects.
Objective: To describe the frequency of differential transplacental passage of antiretrovirals between twins.
Objective: Treatment of coronavirus disease 2019 is mostly symptomatic, but a wide range of medications are under investigation against severe acute respiratory syndrome coronavirus 2. Although pregnant women are excluded from clinical trials, they will inevitably receive therapies whenever they seem effective in nonpregnant patients and even under compassionate use.
Methods: We conducted a review of the literature on placental transfer and pregnancy safety data of drugs under current investigation for coronavirus disease 2019.
Background: Delayed interval delivery is a rare practice aiming at prolonging gestation for the second twin in case of pre-viable birth of twin one. Our objective was to identify factors related to successful delayed delivery of the second twin, among cases in which the interval after delivery of the first twin was above 24h.
Method: A descriptive, retrospective and multicenter study of all delayed interval deliveries in dichorionic twins in 4 perinatal centers in Paris over a 14-year period.