Publications by authors named "Margaux Anav"
[Increasing the cumulative live birth rate: Low-grade blastocysts, potential overlook].
Gynecol Obstet Fertil Senol
December 2024
It is now widely recognized that, following prolonged culture, the transfer of a high-quality morphologically graded blastocyst is the preferred strategy in embryo transfer. Low-grade blastocysts are often considered to have a low implantation potential, and their use remains highly limited. We conducted a general review of the literature, including publications from August 2017 to October 2023, to assess the current state of knowledge regarding these embryos, which are generally excluded in routine practice.
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- The study investigates whether artificial shrinkage of blastocysts before fresh transfer increases clinical pregnancy rates in IVF, involving 150 couples in a randomized and controlled pilot study.
- Results showed no significant differences in clinical pregnancy rates, live birth rates, or other outcomes between the control group and the group that underwent artificial shrinkage.
- The authors conclude that further extensive randomized controlled trials are needed to validate these initial findings.
Article Synopsis
- A balanced interaction between pro- and anti-inflammatory factors is crucial for female reproductive health, with chronic low-grade inflammation affecting conditions related to infertility and embryo implantation.
- This systematic review aimed to analyze how pre-implantation levels of the inflammation marker C-reactive protein (CRP) relate to pregnancy success rates in women receiving assisted reproductive technologies (ART) and to track changes in CRP levels post-implantation.
- The review incorporated 10 studies, finding that lower CRP levels before implantation often correlate with successful ART outcomes, while higher levels are observed during the implantation phase.
Article Synopsis
- - The study compares closed vitrification systems (without direct liquid nitrogen contact) with open systems and aims to report on their effectiveness in egg donation programs.
- - It finds that the number of vitrified oocytes is the main predictor of both survival rates and clinical pregnancy, with a 15% increase in survival odds for each additional oocyte.
- - The outcomes align with established standards, supporting the routine use of closed vitrification systems, but further research with larger sample sizes is needed for broader application.
Article Synopsis
- Birth weight (BW) is generally higher for babies conceived through frozen embryo transfer (FET) compared to fresh embryo transfer, and the study aims to investigate whether the freezing-thawing process contributes to this difference.
- The study analyzed two groups: one with older siblings conceived via fresh embryos and younger siblings via frozen embryos, and another with siblings both conceived through FET from the same embryo cohort.
- Results showed that the average BW for FET babies was significantly higher than for fresh, suggesting that cryopreservation plays a critical role in BW variation, independent of sibling parity.