High adiponectin concentrations are associated with the metabolically healthy obese phenotype.

Context: In the ob/ob mice, keeping adiponectin concentrations in the physiological range (through overexpression of this gene in the adipose tissue) results in expansion of fat mass and protection against metabolic co-morbidities.

Objective: The aim of the study was to test in humans whether plasma adiponectin levels, similar to those found in lean subjects, are associated with the metabolically healthy obese phenotype.

Design And Setting: A cross-sectional analysis was performed of a cohort of obese and nonobese subjects aged 18-70 yr.

Familial combined hyperlipidemia: controversial aspects of its diagnosis and pathogenesis.

Familial combined hyperlipidemia is the most frequent cause of primary dyslipidemia in Mexico. Its manifestations include hypercholesterolemia, hypertriglyceridemia, or a combination of both. Despite its high frequency, a proper diagnosis is rarely made.