Publications by authors named "Margarita Val Arreola"
Article Synopsis
- - Chagas disease, caused by the parasite Trypanosoma cruzi, is prevalent in southern America, and a study tested a new vaccine (TcVac4) in dogs to see how well it protects against this infection.
- - The vaccination involved initial doses of a DNA vaccine followed by inactivated T. rangeli parasites, and the results showed that vaccinated dogs had a stronger immune response and reduced symptoms compared to controls.
- - Post-evaluation revealed that the TcVac4 vaccine improved heart health, decreased parasitic infection severity, and lowered the chance of transmitting the disease to insects, indicating a significant protective effect.
Background: Trypanosoma cruzi, the etiologic agent of Chagas Disease, is a major vector borne health problem in Latin America and an emerging infectious disease in the United States.
Methods: We tested the efficacy of a multi-component DNA-prime/DNA-boost vaccine (TcVac1) against experimental T. cruzi infection in a canine model.